Metallo-aminopeptidase inhibitors
نویسندگان
چکیده
منابع مشابه
Catechoyl-Dipeptides as Leucine Aminopeptidase Inhibitors
Compounds consisting of the catechol group con nected to an amino acid or a small peptide only re cently have been the subject of few papers concern ing their structure-activity relationship. A number of 2,3-dihydroxybenzoic acid amides such as polyamine derivatives: parabactin [1 ], agrobactin [2], vibriobactin [3], or amino acid derivatives: glycine [4], lysine [5], serine [6 ], and threon...
متن کاملThe Activity of a Hexameric M17 Metallo-Aminopeptidase Is Associated With Survival of Mycobacterium tuberculosis
Mycobacterium tuberculosis is one of the most prevalent human pathogens causing millions of deaths in the last years. Moreover, tuberculosis (TB) treatment has become increasingly challenging owing to the emergence of multidrug resistant M. tuberculosis strains. Thus, there is an immediate need for the development of new anti-TB drugs. Proteases appear to be a promising approach and may lead to...
متن کاملSerendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
In this article we describe the application of structural biology methods to the discovery of novel potent inhibitors of methionine aminopeptidases. These enzymes are employed by the cells to cleave the N-terminal methionine from nascent peptides and proteins. As this is one of the critical steps in protein maturation, it is very likely that inhibitors of these enzymes may prove useful as novel...
متن کاملDiscovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers
The hexapeptide angiotensin IV (Ang IV) is a metabolite of angiotensin II (Ang II) and plays a central role in the brain. It was reported more than two decades ago that intracerebroventricular injection of Ang IV improved memory and learning in the rat. Several hypotheses have been put forward to explain the positive effects of Ang IV and related analogues on cognition. It has been proposed tha...
متن کاملOverview Metallo-β-lactamase inhibitors: Promise for the future?
Carbapenem resistance continues to erode the effectiveness of antibiotics such as imipenem and meropenem in the clinic. Resistance mechanisms can include interplay between porin loss (membrane permeability), mutation of penicillin binding proteins necessary for cell division, and expression of class A, B and D β-lactamases. Bacterial resistance to β-lactams such as penicillin or amoxicillin has...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimie
سال: 2010
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2010.04.026